Strain-specific antiviral activity of iminosugars against human influenza A viruses

摘要

Objectives: Drugs that target host cell processes can be employed to complement drugs that specifically target viruses, and iminosugar compounds that inhibit host alpha-glucosidases have been reported to show antiviral activity against multiple viruses. Here the effect and mechanism of two iminosugar alpha-glucosidase inhibitors, N-butyl-deoxynojirimycin (NB-DNJ) and N-nonyl-deoxynojirimycin (NN-DNJ), on human influenza A viruses was examined.