Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses

Zvada Simbarashe P.; Denti Paolo; Donald Peter R.; Schaaf H. Simon; Thee Stephanie; Seddon James A.; Seifart Heiner I.; Smith Peter J.; McIlleron Helen M.; Simonsson Ulrika S. H.

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Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses

机译：结核病儿童中利福平，吡嗪酰胺和异烟肼的群体药代动力学：目前推荐剂量的计算机评估

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摘要

To describe the population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children and evaluate the adequacy of steady-state exposures.

机译：描述儿童中利福平，吡嗪酰胺和异烟肼的群体药代动力学，并评估稳态暴露的适当性。

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《The Journal of Antimicrobial Chemotherapy》 |2014年第5期|共11页
作者
Zvada Simbarashe P.; Denti Paolo; Donald Peter R.; Schaaf H. Simon; Thee Stephanie; Seddon James A.; Seifart Heiner I.; Smith Peter J.; McIlleron Helen M.; Simonsson Ulrika S. H.;
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正文语种 eng
中图分类治疗学;
关键词
pharmacometrics; anti-Mycobacterium; paediatrics; NONMEM; modelling and simulation;

机译：药理学;抗分枝杆菌;儿科;NONMEM;建模与模拟;

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1. Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses [J] . Zvada Simbarashe P., Denti Paolo, Donald Peter R., The Journal of Antimicrobial Chemotherapy . 2014,第5期

机译：结核病儿童中利福平，吡嗪酰胺和异烟肼的群体药代动力学：目前推荐剂量的计算机评估
2. Pharmacokinetics of thrice-weekly rifampicin, isoniazid and pyrazinamide in adult tuberculosis patients in India [J] . Kumar A. K. Hemanth, Kannan T., Chandrasekaran V., The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease . 2016,第9期

机译：印度成年结核病患者每周三次利福平，异烟肼和吡嗪酰胺的药代动力学
3. Simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol in fixed-dose combination antituberculosis pharmaceutical formulations: a review [J] . M. A. L. Oliveira, P. R. Chellini, T. L. Amorim Analytical methods . 2018,第10期

机译：固定剂量联合抗结核药物制剂中利福平，异烟肼，吡嗪酰胺和乙胺丁醇的同时测定：综述
4. Enhancing MALDI MS Signals through Chemistry: Analysis of Isoniazid Dosed Animals in Tuberculosis Studies [C] . M. Lisa Manier, Michelle L. Reyzer, Joey C. Latham, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：通过化学增强马尔迪MS信号：分析结核病研究中的异喹啉剂
5. Treatment of latent tuberculosis infection with isoniazid (INH) for nine months versus rifampin and pyrazinamide (RZ) for two months: A comparison of rate of liver injury in Baltimore City Chest Clinic during 1999--2001. [D] . Obiako, Emmanuel Chinasa. 2007

机译：异烟肼（INH）与利福平和吡嗪酰胺（RZ）两个月治疗潜伏性肺结核感染九个月：巴尔的摩市胸科诊所1999--2001年肝损伤率的比较。
6. Population pharmacokinetics of rifampicin pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses [O] . Simbarashe P. Zvada, Paolo Denti, Peter R. Donald, -1

机译：结核病儿童中利福平吡嗪酰胺和异烟肼的群体药代动力学：目前推荐剂量的计算机评估
7. Population pharmacokinetics, optimised design and sample size determination for rifampicin, isoniazid, ethambutol and pyrazinamide in the mouse [O] . Chen, Chunli, Ortega, Fatima, Alameda, Laura, 2016

机译：小鼠中利福平，异烟肼，乙胺丁醇和吡嗪酰胺的群体药代动力学，优化设计和样品量测定

Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses

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