S-nitrosoglutathione (GSNO) is cytotoxic to intracellular amastigotes and promotes healing of topically treated Leishmania major or Leishmania braziliensis skin lesions-authors' response

摘要

Thank you to Ronzani et al. for calling attention to our paper. The results reported by Ronzani et al. are certainly interesting as they indicate that expression of chemokines and cytokines in a human monocyte cell line (THP-1) can be up-regulated by S-nitrosoglutathione (GSNO). Although most studies have reported down-regulation of the synthesis of most proteins, up-regulation also occurs and the net result of GSNO action appears to be much dependent on the levels of nitrosoglutathione reductase expressed by each cell type.