The enterococcal ABC transporter gene lsa(E) confers combined resistance to lincosamides, pleuromutilins and streptogramin A antibiotics in methicillin-susceptible and methicillinresistant Staphylococcus aureus

摘要

In recent years, combined resistance to lincosamides, pleuromuti-lins and streptogramin A antibiotics in staphylococci has been attributed to ABC transporters of the Vga type. Besides variants of the vgo(A) gene,1 novel genes such as vga(C) and vga(E) have been detected in methicillin-resistant Staphylococcus aureus (MRSA) of clonal complex (CC) 398 of swine, cattle and poultry origin and shown to confer this resistance phenotype.2^5 In En-terococcus faecolis and Streptococcus agalactiae, the genes lsa(A) and Iso(C), respectively, which also encode ABC transporters, mediate a similar resistance phenotype.6'7 In a recent study by Lozano and co-workers,8 a 12120 bp segment was sequenced (GenBank accession no. JQ861959) to gain insight into the genetic environment of the lincosamide nucleotidyltransferase gene lnu{B) in one MRSA isolate of sequence type (ST) 398 and two methicillin-susceptible S. aureus (MSSA) ST9 isolates of human origin.