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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Pedein A and B: Production, Isolation, Structure Elucidation and Biological Properties of New Antifungal Cyclopeptides from Chondromyces pediculatus (Myxobacteria).
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Pedein A and B: Production, Isolation, Structure Elucidation and Biological Properties of New Antifungal Cyclopeptides from Chondromyces pediculatus (Myxobacteria).

机译:Pedein A和B:来自小花软骨线虫(Myxobacteria)的新型抗真菌环肽的生产,分离,结构解析和生物学特性。

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摘要

Two new secondary metabolites, named pedein A and B, were isolated from the cell mass of the myxobacterium Chondromyces pediculatus. Their planar structures were elucidated by spectroscopic methods, in particular 2D NMR as 24-membered cyclic hexapeptides composed of a variable tryptophan residue, glycine, sarcosine and three unusual hydroxy beta- and gamma-amino acids. The main component, pedein A, strongly inhibited the growth of yeasts and fungi, induced hemolysis of erythrocytes, and caused changes in membrane permeability of Rhodotorula glutinis. The structures of the pedeins are closely related to the large family of the microsclerodermins, which have been isolated from lithistid sponges of Microscleroderma and Theonella species.
机译:从粘液线粒体软骨细胞的细胞团中分离出两种新的次生代谢产物,分别称为pedein A和B。通过光谱方法,特别是2D NMR,阐明了它们的平面结构,其为由可变色氨酸残基,甘氨酸,肌氨酸和三种不同的羟基β-和γ-氨基酸组成的24元环六肽。主要成分pedein A强烈抑制酵母菌和真菌的生长,诱导红细胞溶血,并导致红假单胞菌的膜通透性发生变化。脚踏蛋白的结构与微菌皮蛋白的大家族紧密相关,微菌皮蛋白已从微菌皮和Theonella菌种的直链海绵中分离出来。

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