3-Normeridamycin:A Potent Non-lmmunosuppressive Immunophilin Ligand is Neuroprotective in Dopaminergic Neurons

摘要

3-Normeridamycin (1), isolated from fermen-tation extracts of the soil actinomycete Streptomyces sp.LL-C31037, demonstrated potent neuroprotective activity.When challenged with the neurotoxin 1-methyl-4-phenylpyridinium (MPP~+), known to induce parkinsonism, 1 restored functional dopamine uptake in a concentration-dependent manner, with an EC_(50) of 110nM in dopaminergic neurons.The structure of 1 was determined via spectroscopic methods, and the immunosuppressive and immunophilin binding properties of the compound were also measured.