Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults

摘要

To the Editor: Prevailing clinical experience suggests that allergic patients can become sensitized to new allergen source's in the natural course of their allergic disease and thus expand their IgE reactivity profiles.1 However, there are no experimental studies that have used defined allergen molecules to investigate whether the appearance of allergic reactions against new allergen sources results from true de novo IgE sensitizations against new allergen molecules or from the augmentation of already existing IgE sensitizations passing the threshold required for clinical manifestation.