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首页> 外文期刊>The Journal of Allergy and Clinical Immunology >Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children.
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Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children.

机译:特应性和非特应性儿童针对白喉-破伤风-百日咳疫苗的破伤风类毒素和百日咳杆菌粘附素抗原的免疫记忆的开发。

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摘要

BACKGROUND: Recent findings suggest that a hallmark of the atopic phenotype is reduced capacity to respond to vaccine antigens, as well as to environmental allergens, during infancy. This deficiency, which is most marked for the cytokine IFN-gamma, appears transient but can result in a long-lasting imbalance within T helper cell (T(H)) memory responses to allergens. Indirect evidence suggests that parallel effects may occur within immunologic memory responses against vaccine antigens in atopic children. OBJECTIVE: Our purpose was to compare vaccine antigen-specific T(H) memory responses in atopic and nonatopic children. METHODS: We analyzed specific serum IgG and cytokine responses to pertactin and tetanus antigens as well as to mitogen (PHA) and house dust mite (HDM) allergen in 25 HDM-sensitized atopic and 25 nonatopic 6-year-old children who were vaccinated and boosted with diphtheria-tetanus-pertussis (DTP) vaccine. RESULTS: PBMCs from the atopic subjects produced higher levels of T(H)1 and T(H)2 cytokines to HDM allergen and PHA. Vaccine antibody titers were normal in the atopic subjects; vaccine-specific T(H)2 responses were rarely detectable, yet T(H)1 (IFN-gamma) responses, in particular against tetanus, were frequent and higher in the atopic subjects (121.5 [SE 64.3] vs 8.0 [3.5] pg/mL culture fluid, P =.04). Corresponding pertactin responses were comparable in both groups. CONCLUSIONS: At the completion of the full primer-booster DTP vaccination regimen, levels of vaccine-specific immunity in atopic 6-year-old children are at least equivalent to their nonatopic counterparts, indicating that the transient atopy-associated deficiency in T(H)1 function in childhood can be successfully overcome by appropriate vaccination and boosting regimens.
机译:背景:最近的发现表明,特应性表型的标志是婴儿期对疫苗抗原以及环境变应原的反应能力降低。这种缺陷是细胞因子IFN-γ最明显的缺陷,看起来是暂时的,但会导致T辅助细胞(T(H))对变应原的记忆反应长期不平衡。间接证据表明,在特应性儿童针对疫苗抗原的免疫记忆反应中可能发生平行作用。目的:我们的目的是比较特应性和非特应性儿童的疫苗抗原特异性T(H)记忆反应。方法:我们分析了25名接受过HDM过敏的特应性和25名非特应性6岁儿童的特异性血清IgG和细胞因子对百日咳杆菌毒素和破伤风抗原以及对有丝分裂原(PHA)和屋尘螨(HDM)过敏原的反应。用白喉-破伤风-百日咳(DTP)疫苗加强免疫。结果:特应性受试者的PBMC对HDM过敏原和PHA产生更高水平的T(H)1和T(H)2细胞因子。特应性受试者的疫苗抗体滴度正常。疫苗特异的T(H)2应答很少检测到,但是特应性受试者中T(H)1(IFN-γ)应答,尤其是针对破伤风的应答频繁且更高(121.5 [SE 64.3] vs 8.0 [3.5] pg / mL培养液,P = .04)。两组中相应的百日咳杆菌粘附素反应相当。结论:在完成完整的引物-booster DTP疫苗接种方案后,特应性6岁儿童的疫苗特异性免疫水平至少与他们的非特应性免疫缺陷疫苗相当,这表明短暂性特应性相关的T(H)缺乏症。 )1儿童时期的功能可以通过适当的疫苗接种和加强疗法来成功克服。

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