Variant Alzheimer's disease with spastic paraparesis and supranuclear gaze palsy

摘要

Variant Alzheimer's disease (VarAD) is a rare form of familial Alzheimer's disease (AD) and is clinically characterized by progressive dementia which in most cases, is preceded by spastic paraparesis (SP). The clinical diagnosis of VarAD may be difficult in families without a strong family history of dementia and in subjects presenting with paraparesis as the initial symptom.