When working with systems that are either suspensions of submicron particles or solutions of molecules, including proteins and other macromolecules, there are three key parameters that are often used to provide information about their behaviour, stability and chemistry. These are particle size, zeta potential and molecular weight. The advent of a system that incorporates the hardware and software for combined dynamic, static and electrophoretic light scattering measurements now offers access to allthese sample properties using a single analytical instrument (Zetasizer Nano ZS, Malvern Instruments). This article briefly reviews the technology involved and some of its applications in biomolecular research.
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