Value of s-ACE, BAL lymphocytosis, and CD4 +/CD8+ and CD103+CD4+/CD4+ T-cell ratios in diagnosis of sarcoidosis

摘要

Sarcoidosis is one of the most common causes of idiopathic lung disease. The international standard for diagnosis of sarcoidosis is based on three criteria: 1) a compatible clinical and/or radiological presentation; 2) histological evidence of noncaseat-ing granulomas; and 3) exclusion of other diseases that produce a similar histological or clinical picture [1]. The diagnosis of sarcoidosis is supported by an elevated CD4+/CD8+ T-cell ratio, bronchoalveolar lavage (BAL) lymphocytosis and elevated serum angiotensin-converting enzyme (s-ACE). However, these parameters are variable in sarcoidosis