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A toy model of fractal glioma development under RF electric field treatment

机译:射频电场治疗下的分形神经胶质瘤发展的玩具模型

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摘要

A toy model for glioma treatment by a radio frequency electric field is suggested. This lowintensity, intermediate-frequency alternating electric field is known as the tumor-treating field (TTF). In the framework of this model the efficiency of this TTF is estimated, and the interplay between the TTF and the migration-proliferation dichotomy of cancer cells is considered. The model is based on a modification of a comb model for cancer cells, where the migration-proliferation dichotomy becomes naturally apparent. Considering glioma cancer as a fractal dielectric composite of cancer cells and normal tissue cells, a new effective mechanism of glioma treatment is suggested in the form of a giant enhancement of the TTF. This leads to the irreversible electroporation that may be an effective non-invasive method of treating brain cancer.
机译:提出了一种通过射频电场治疗神经胶质瘤的玩具模型。这种低强度的中频交变电场称为肿瘤治疗场(TTF)。在该模型的框架中,估计了该TTF的效率,并考虑了TTF与癌​​细胞迁移-扩散二分法之间的相互作用。该模型基于针对癌细胞的梳形模型的修改,其中迁移-扩散二分法变得自然可见。考虑到神经胶质瘤癌症是癌细胞和正常组织细胞的分形介电复合物,以巨幅增强TTF的形式提出了一种新的神经胶质瘤治疗有效机制。这导致不可逆的电穿孔,这可能是治疗脑癌的有效非侵入性方法。

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