Authors' reply

摘要

We agree with Professor Kopp that hyperoxia during surgical anaesthesia might contribute to the higher risk of dementia following anaesthesia and surgery. Growing evidence has demonstrated that oxidative stress may augment the production and aggregation of amyloid-beta and facilitate the phosphorylation of tau. Evidence has suggested that oxidative stress is an important factor contributing to the initiation and progression of Alzheimer's disease. Animal and human studies have also demonstrated increased oxidative stress following anaesthesia and surgery.