HOBt and HOAt-derived immonium salts:new and highly efficient coupling reagents for pertide synthesis

摘要

Novel HOBt- and HOAt-derived immonium type coupling reagents BDMP,BPMP and AOMP were shown to be very efficient for peptide synthesis with high reactivity, low racemization and good yields.X-Ray analysis indicates BOMI exists as the N-substituted form rather than as the O-substituted form assigned previously.A mechanism for amide bond formation mediated by these reagents was proposed and studied.