Synthesis of new baccatin III derivatives through transesterification of #beta#-keto esters with a protected 10-deacetylbaccatin III

Mandai Tadakatsu; Kuroda Akiyoshi; Okumoto Hiroshi; Nakanishi Katsuyoshi; Mikuni Katsuhiko; Hara Ko-ji; Hara Ko-zo

首页> 外文期刊>Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry >Synthesis of new baccatin III derivatives through transesterification of #beta#-keto esters with a protected 10-deacetylbaccatin III

【24h】

Synthesis of new baccatin III derivatives through transesterification of #beta#-keto esters with a protected 10-deacetylbaccatin III

机译：通过与受保护的10-去乙酰基浆果赤霉素III酯交换＃beta＃-酮酯合成新的浆果赤霉素III衍生物

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Synthesis of a new array of baccatin III derivatives bearing a #beta#-keto ester appendage on C-13 is successfully achieved through transesterification of a wide range of #beta#-keto esters with a protected baccatin III.

机译：通过用保护的浆果赤霉素III对广泛范围的＃β＃-酮酯进行酯交换反应，成功地合成了一系列新的浆果赤霉素III衍生物（在C-13上带有＃β＃-酮酯）。

著录项

来源
《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |2000年第2期|共4页
作者
Mandai Tadakatsu; Kuroda Akiyoshi; Okumoto Hiroshi; Nakanishi Katsuyoshi; Mikuni Katsuhiko; Hara Ko-ji; Hara Ko-zo;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
beta; -keto ester; 10-deacetylbaccatin III; transesterification; paclitaxel;

机译：β;-酮酸酯;10-去乙酰基浆果赤霉素III;酯交换反应;紫杉醇;
入库时间 2022-08-18 17:44:25

相似文献

外文文献
中文文献
专利

1. Synthesis of new baccatin III derivatives through transesterification of #beta#-keto esters with a protected 10-deacetylbaccatin III [J] . Mandai Tadakatsu, Kuroda Akiyoshi, Okumoto Hiroshi, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2000,第2期

机译：通过与受保护的10-去乙酰基浆果赤霉素III酯交换＃beta＃-酮酯合成新的浆果赤霉素III衍生物
2. Total asymmetric synthesis of taxol by dehydration condensation between 7-TES baccatin III and protected N-benzoylphenylisoserines prepared by enantioselective aldol reaction [J] . Shiina I., Frechard-Ortuno I., Mukaiyama T., Chemistry Letters . 1998,第1期

机译：通过7-TES浆果赤霉素III与对映选择性醛醇缩合反应制备的受保护的N-苯甲酰基苯基异丝氨酸之间的脱水缩合，可完全不对称合成紫杉醇
3. Computer-assisted automated synthesis.III. Synthesis of substituted N-(carboxyalkyl) amino-acid tert-butyl ester derivatives [J] . NobuyoshiHayashi, TohruSugawara, ShinjiKato Journal of Analytical Methods in Chemistry . 1991,第5期

机译：计算机辅助的自动合成。取代的N-（羧基烷基）氨基酸叔丁酯衍生物的合成
4. Novel synthesis and application of a protected bicyclic alpha-helix initiating heptapeptide suitable for segment condensation synthesis:utility of pentaaminecobalt(III) for carboxyl protection [C] . John W.Taylor, Prasanna Reddy, Ketal Patel, the International Peptide Symposium . 2001

机译：保护双环α-螺旋引发七肽适用于分析缩合合成的新型合成及应用：羧基保护硅酸（III）的效用
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. Computer-assisted automated synthesis.III. Synthesis of substituted N-(carboxyalkyl) amino-acid tert-butyl ester derivatives [O] . Nobuyoshi Hayashi, Tohru Sugawara, Shinji Kato 1991

机译：计算机辅助的自动合成。三取代的N-（羧烷基）氨基酸叔丁酯衍生物的合成
7. Metabotropic glutamate receptor 3 neuroprotection A. Berent-Spillson and J. W. Russell Received June 12, 2006; revised manuscript received October 3, 2006; accepted October 5, 2006. Address correspondence and reprint requests to James W. Russell, Department of Neurology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201-1595, USA. E-mail: jruss@umich.edu Abbreviations used : APDC , 2 R ,4 R -4-aminopyrrolidine-2,4-dicarboxylate (specific metabotropic glutamate receptor 3 agonist) ; BSO , buthionine sulfoximine (GSH synthesis inhibitor) ; caspase , cysteine-requiring aspartate protease ; CysGly , cysteinylglycine (GSH degradation product) ; DAPI , 4′-6-diamidino-2-phenylindole ; DCF , dichlorodihydrofluorescein ; DCFDA , 5-(and 6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester ; DHE , dihydroethidium ; DRG , dorsal root ganglion ; FCCP , carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (electron transport uncoupler) ; GCP II/III , glutamate carboxypeptidase II/III ; GSH , glutathione ; GSH-EE , glutathione ethyl ester ; GST , glutathione-s-transferase ; H 2 O 2 , hydrogen peroxide ; HBSS , Hank’s balanced salt solution ; JC-1 , 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide ; MCB , monochlorobimane ; mGluR , metabotropic glutamate receptor ; NAAG , N -acetyl-aspartyl-glutamate ; PBS , phosphate-buffered saline ; PCD , programmed cell death ; Rh123 , rhodamine123 ; ROS , reactive oxygen species ; δψ μ , inner mitochondrial membrane potential . Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration [O] . Berent-Spillson Alison, Russell James W. 2007

机译：代谢型谷氨酸受体3神经保护a. Berent-spillson和J. W. Russell于2006年6月12日收到;修订稿于2006年10月3日收到; 2006年10月5日接受。美国马里兰州巴尔的摩市南格林街22号，马里兰大学医学院神经病学系James W. Russell的地址通信和重印申请。电子邮件：jruss@umich.edu使用的缩写：apDC，2R，4R-4-氨基吡咯烷-2,4-二羧酸酯（特异性代谢型谷氨酸受体3激动剂）; BsO，丁硫氨酸亚砜亚胺（GsH合成抑制剂）;半胱天冬酶，半胱氨酸需要的天冬氨酸蛋白酶; CysGly，半胱氨酰甘氨酸（GsH降解产物）; DapI，4'-6-二脒基-2-苯基吲哚; DCF，二氯二氢荧光素; DCFDa，5-（和6） - 氯甲基-2'，7'-二氯二氢荧光素二乙酸酯，乙酰酯; DHE，二氢乙锭; DRG，背根神经节; FCCp，羰基氰化物4-（三氟甲氧基）苯腙（电子传输解偶联剂）; GCp II / III，谷氨酸羧肽酶II / III;谷胱甘肽;谷胱甘肽; GsH-EE，谷胱甘肽乙酯; GsT，谷胱甘肽-s-转移酶; H 2 O 2，过氧化氢; HBss，Hank的平衡盐溶液; JC-1,5,5'，6,6'-四氯-1,1'，3,3'-四乙基苯并咪唑基酞菁碘化物; mCB，monochlorobimane; mGluR，代谢型谷氨酸受体; NaaG，N-乙酰基 - 天冬氨酰谷氨酸; pBs，磷酸盐缓冲盐水; pCD，程序性细胞死亡; Rh123，罗丹明123;活性氧，活性氧; δψμ，线粒体内膜电位。代谢型谷氨酸受体3通过增加细胞内谷胱甘肽浓度来保护神经元免受葡萄糖诱导的氧化损伤
8. Oxy and Thio Phosphorus Acid Derivatives of Tin. VIII. The Tin(II) Bis-(dithiophosphate) Esters and Their Bipyridyl Adducts. The X-Ray Crystal and Molecular Structure of Bis-(O,O'-Diphenyldithiophosphato)tin(II) [R] . Lefferts, J. L., Molloy, K. C., Helm, D., 1981

机译：锡的氧化和硫代磷酸衍生物。八。锡（II）双 - （二硫代磷酸酯）酯及其联吡啶加合物。双 - （O，O'-二苯基二硫代磷酸）锡（II）的X射线晶体和分子结构

Synthesis of new baccatin III derivatives through transesterification of #beta#-keto esters with a protected 10-deacetylbaccatin III

摘要

著录项

相似文献

相关主题

期刊订阅