Preparation of 2-amino-2 '-hydroxy-1,1 '-binaphthyl and N-arylated 2-amino-1,1 '-binaphthyl derivatives via palladium-catalyzed amination

摘要

Palladium-catalyzed amination reactions were carried out with 2-triflato-2'-(4-methoxybenzyloxy)-1,1'-binaphthyl (5) and benzophenone imine followed by hydrolysis of the imine and hydrogenolysis of the benzyl protecting group to afford 2-amino-2'-hydroxy-1,1'-binaphthyl (1). Arylamines were also coupled successfully with 5 under similar conditions. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 13]