Diastereoselective reduction of (S)-1-chloro-3-silyloxybutan-2-one. Synthesis of enantiopure (2S,3R) and (2S,3S) O-tert-butyldimethylsilyl-3,4-epoxybutan-2-ol.

Concellon JM.; Alvarez R.; Rodriguez A.; Baragana B.; Bernad PL.

首页> 外文期刊>Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry >Diastereoselective reduction of (S)-1-chloro-3-silyloxybutan-2-one. Synthesis of enantiopure (2S,3R) and (2S,3S) O-tert-butyldimethylsilyl-3,4-epoxybutan-2-ol.

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Diastereoselective reduction of (S)-1-chloro-3-silyloxybutan-2-one. Synthesis of enantiopure (2S,3R) and (2S,3S) O-tert-butyldimethylsilyl-3,4-epoxybutan-2-ol.

机译：（S）-1-氯-3-甲硅烷氧基丁烷-2-酮的非对映选择性还原。对映纯（2S，3R）和（2S，3S）O-叔丁基二甲基甲硅烷基-3,4-环氧丁烷-2-醇的合成。

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(2S,3S)- And (2R,3S)-3-[(tert-butyldimethyl)silyloxy]-1-chlorobutan-2-ol have been obtained with high diastereoselectivity by reduction of enantiopure (S)-3-[(tert-butyldimethyl)silyloxy]-1-chlorobutan-2-one using different reducing agents. The chiral alcohols were transformed into the corresponding (2R,3S)- and (2S,3S)-3-[(tert-butyldimethyl)silyloxy]-1,2-epoxybutane. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 4]

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |1999年第14期|共2页
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Concellon JM.; Alvarez R.; Rodriguez A.; Baragana B.; Bernad PL.;
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正文语种 eng
中图分类有机化学;
关键词
Chiral chloromethyl ketones; Reduction; Diastereoselection; Beta; gamma-epoxy alcohols; Derivatives;

机译：手性氯甲基酮;还原;非对映异构;β;γ-环氧醇;衍生物;

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1. Diastereoselective reduction of (S)-1-chloro-3-silyloxybutan-2-one. Synthesis of enantiopure (2S,3R) and (2S,3S) O-tert-butyldimethylsilyl-3,4-epoxybutan-2-ol. [J] . Concellon JM., Alvarez R., Rodriguez A., Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1999,第14期

机译：（S）-1-氯-3-甲硅烷氧基丁烷-2-酮的非对映选择性还原。对映纯（2S，3R）和（2S，3S）O-叔丁基二甲基甲硅烷基-3,4-环氧丁烷-2-醇的合成。
2. Synthesis of (2R,3S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-(4-bromophenyl)-3-(tert-butoxy-carbonylamino)-tetrahydrofuran-3-carboxylate and (2S,3R)-((1R,2S,5R)-2-isopropyl- 5-methylcyclohexyl)2-(4- bromophenyl)-3-(tert-butoxy?carbonyl?amino)-tetrahydrofuran-3-carboxylate [J] . Andreas Grauer, Burkhard K?nig Molbank . 2009,第1期

机译：（2R，3S）-（（1R，2S，5R）-2-异丙基-5-甲基环己基）2-（4-溴苯基）-3-（叔丁氧基羰基氨基）-四氢呋喃-3-羧酸酯的合成和（ 2S，3R）-（（（1R，2S，5R）-2-异丙基-5-甲基环己基）2-（4-溴苯基）-3-（叔丁氧基？羰基？氨基）-四氢呋喃-3-羧酸酯
3. SYNTHESIS OF (2R,3S)- OR (2S,3R)-2-AMINO-3-TRIFLUOROMETHYL-3-HYDROXYALKANOIC ACID DERIVATIVES (THREONINE AND ALLO-THREONINE ANALOGS) FROM ENANTIOPURE 4,4,4-TRIFLUORO-3-HYDROXYBUTANOIC ACID [J] . Sting AR., Seebach D. Tetrahedron . 1996,第1期

机译：从对映体4,4,4-三氟-3-丁二酸合成（2R，3S）-或（2S，3R）-2-氨基-3-三氟-3-甲基羟基苏糖酸衍生物（苏氨酸和别铝-苏氨酸）
4. Energy Calculation For Beryllium Atom in Different Excited States (1s~2 2s 3s), (1s 2s~2 3s) and (1s 2s 3s~2) [C] . Mayada J. Al-Sharaa, Maysoon A. Mahmood, Naaemh CH. Madhkoor, International Conference and Workshops on Basic and Applied Sciences . 2017

机译：不同激发态中铍原子的能量计算（1S〜2 2S 3S），（1S 2S〜2 3S）和（1S 2S 3S〜2）
5. Part A. Chemical neutron activation analysis of aluminum in biological samples. Part B. Stereochemical consequences of chlorine substitution reactions with (2S,3S)dl-2-chloro-3-fluoropentane and (2S,3S)dl-3-chloro-2-fluoropentane in the gas, liquid and solid phase. [D] . Roman, Felix R. 1989

机译：A部分：生物样品中铝的化学中子活化分析。 B部分。在气相，液相和固相中与（2S，3S）dl-2-氯-3-氟戊烷和（2S，3S）dl-3-氯-2-氟戊烷的氯取代反应的立体化学结果。
6. Enantioselective Synthesis of (2R 3S)- and (2S 3R)-444-trifluoro-N-Fmoc-O-tert-butyl-threonine and their Racemization-free Incorporation into Oligopeptides via Solid-phase Synthesis [O] . Nu Xiao, Zhong-Xing Jiang, Y. Bruce Yu -1

机译：（2R3S）-和（2S3R）-444-三氟-N-Fmoc-O-叔丁基苏氨酸的对映选择性合成及其通过固相合成将其无消旋地引入寡肽
7. Synthesis of (2R,3S)-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 2-(4-bromophenyl)-3-(tert-butoxy-carbonylamino)-tetrahydrofuran-3-carboxylate and (2S,3R)-((1R,2S,5R)-2-isopropyl- 5-methylcyclohexyl)2-(4- bromophenyl)-3-(tert-butoxy¬carbonyl¬amino)-tetrahydrofuran-3-carboxylate [O] . Andreas Grauer, Burkhard König 2009

机译：（2R，3S）-（（（1R，2S，5R）-2-异丙基-5-甲基环己基）2-（4-溴苯基）-3-（叔丁氧基羰基氨基）-四氢呋喃-3-羧酸酯的合成和（ 2S，3R）-（（（1R，2S，5R）-2-异丙基-5-甲基环己基）2-（4-溴苯基）-3-（叔丁氧基羰基氨基）-四氢呋喃-3-羧酸酯

Diastereoselective reduction of (S)-1-chloro-3-silyloxybutan-2-one. Synthesis of enantiopure (2S,3R) and (2S,3S) O-tert-butyldimethylsilyl-3,4-epoxybutan-2-ol.

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