CONVENIENT SYNTHESIS OF 2,2-DISUBSTITUTED-2,3-DIHYDRO-1,4-BENZODIOXINS FROM 2-SUBSTITUTED-2-HYDROXY-2,3-DIHYDRO-1,4-BENZODIOXINS

摘要

Convenient syntheses of relatively rare 2,2-disubstituted-2,3-dihydro-1,4-benzodioxins from 2-substituted-2-hydroxy 2,3-dihydro-1,4-benzodioxins, as key synthetic intermediates, are reported. These new synthetic approaches require Lewis acid BF3-Et(2)O mediated nucleophilic substitution reaction or cyclization of suitable hydroxyphenols. (C) 1997, Elsevier Science Ltd. [References: 34]