An 8-aminoimidazo[4,5-g]quinazoline carbocyclic nucleoside: a ring-extended analog of 5'-noraristeromycin

摘要

The antiviral properties of 5'-noraristeromycin (3) have been attributed to its inhibiton of S-adenosylhomocysteine hydrolase. As part of an effort to establish the limiting structural parameters posible for the biological properties of 3, a ring-extended analog possessing 8-aminoimidazo[4,5-g]quinazoline as the base (7) has been prepared and found to be less active than 3.