REDUCTIVE DEPROTECTION OF ALLYL, BENZYL AND SULFONYL SUBSTITUTED ALCOHOLS, AMINES AND AMIDES USING A NAPHTHALENE-CATALYSED LITHIATION

摘要

The reaction of different protected alcohols, amines and amides with lithium and a catalytic amount of naphthalene (4 mol %) in THF at low temperature leads to their deprotection under very mild reaction conditions, the process being in many cases chemoselective. (C) 1997 Elsevier Science Ltd. [References: 65]