Studies on chemical modification of monensin VIII.Synthesis of 7-O-substituted -25-carboxymonensins and their Ca~(2+) ion trransport activity

摘要

Monensin (1),an ionophore antibiotic agent,was converted to 25-carboxymonensin (2) adn 7-O-substituted 25-carboxyl derivatives (3a-b),which have two carboxyl groups at both ends of teh molecule,Ca~(2+) ion transport activity of the dicarboxylic monensins was evaluated by teh CHCl_3 liquid membrane method,and 25-carboxymonensins (2 and 3a-d) were shown to transport the Ca~(2+) ion through the CHCl_3 liquid membrane.