Development of a Method for the Preparation of #alpha#-Azido-Masked Acyl Cyanides, Synthetic Equivalents of N-Protected-C-A ctivated #alpha#-Amino Acids

摘要

A method for the preparation of #alpha#-azido-masked acyl cyanides as synthetic equivalents of N-protected-Cactivated #alpha#-amino acids was developed using carbon-carbon bond formation between aldehydes and the Masked Acyl Cyanide Reagents, followed by sulfonylation and substitution by azide anion. This method was applied to the synthesis of D-threonine and L-allo-threonine derivatives.