Functional characteristics of histone H3 kinases MSK1 and MSK2 in oncogene-transformed cells

摘要

Stimulation of the Ras-MAPK signal transduction pathway by growth factors (EGF) or phorbol esters (TPA) in parental (IOTV2) and oncogene (H-ras)-transformed (Ciras-3) mouse fibroblasts induces rapid phosphorylation of histone H3. Phosphorylation of H3 occurs on SerlO and Ser28 in the NH_2-terminal tail. This phosphorylation event is implicated in the transcriptional regulation of immediate early genes, such as c-fos and c-jun.