Chiral alpha,omega-diaminoethers derived from D-mannitol and L-treitol as building blocks for the synthesis of macrocyclic compounds possessing 1,3-benzenedicarboxamide or 2,6-pyridinedicarboxamide subunits

摘要

Three new chiral alpha,omega -diaminoethers, derivatives Of D-mannitol and L-treitol, possessing C-2 symmetry are prepared. The alpha,omega -diaminoethers were applied to the macrocyclization reaction under non-high-dilution conditions, which afforded chiral macrocyclic diamides possessing either 2,6-pyridinedicarboxamide or 1,3-benzenedicarboxamide moieties. (C) 2001 Elsevier Science Ltd. All rights reserved. [References: 32]