Asymmetric hydrogenation of imines and olefins using phosphine-oxazoline iridium complexes as catalysts

摘要

Herein we describe the synthesis of a new class of chiral phosphine-oxa- zolines and their application as ligands in iridium-catalyzed hydrogenations. Mechanistic aspects of olefin hydrogenation with this class of iridium catalysts are discussed and a selectivity model to help rationalize the results obtained is also presented.