Axially chiral C_2-symmetric N-heterocyclic carbene (NHC) palladium complex-catalyzed asymmetric α-hydroxylation of β-keto esters

摘要

Axially chiral C_2-symmetric N-heterocyclic carbene (NHC) palladium diaquo complexes 1a and 1b, derived from (R)-BINAM, are effective catalysts for the enantioselective α-hydroxylation of β-keto esters using oxaziridine 2a as the oxidant to give the corresponding products in high yields along with moderate enantioselectivities.