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FALSE ELEVATION OF BLOOD GLUCOSE LEVELS MEASURED BY GDH-PQQ-BASED

机译:基于GDH-PQQ的血糖水平虚假升高

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Chiu-Yeh Tsai,Su-Chu Lee, Chi-Chih Hung, Jia-Jung Lee, Mei-Chuan KuoDepartment of Nursing, Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University HospitalObjective: False elevation of blood glucose levels measured by glucose dehydrogenase pyrroloquinoline quinone (GDH-PQQ)-based glucose self-monitoring systems; glucometer) in peritoneal dialysis (PD) patients using ico-dextrin solution has been well documented. However, adverse hypoglycemic events caused by misreadings for blood glucose are still being reported. We aimed to study blood glucose levels measured simultaneously using different methods in PD patients with switching of icodextrin, and throughout daily exchanges either using icodextrin or not.Design: We recruited 100 PD patients, including 40 using icodextrin; 128 hemodialysis patients served as a reference. Fasting serum glucose was measured using our laboratory reference method (LAB) and 2 glucose self-monitoring systems based on glucose dehydrogenase nicotinamide ad-enine dinucleotide (GDH-NAD) and GDH-PQQ respectively. 80 PD patients had a second follow-up study. A time course study was performed in 16 PD patients through measuring fingertip glucose using the 2 glucose self-monitoring systems during daily exchanges.Result The differences in measured serum glucose levels in (PQQ minus LAB) versus (NAD minus LAB) were markedly increased in PD patients using icodextrin compared to other patient groups, and was further confirmed by the follow-up study in patients that switched to icodextrin. The high serum glucose levels measured by the GDH-PQQ-based glucose self-monitoring system were present throughout all exchanges during the day in patients using icodextrin solution.Conclusion: False elevation of blood glucose measured by GDH-PQQ-based glucose self-monitoring systems exists in patients using icodextrin. To avoid misinterpretation of hyperglycemia and subsequent over-injection of insulin.GDH-PQQ-based glucose self-monitoring systems should not be used in PD patients.
机译:蔡超业,李苏初,洪志智,李嘉J,郭美全高雄医科大学附属医院内科肾内科护理学目的:用葡萄糖测得的血糖水平错误升高基于脱氢酶吡咯并喹啉醌(GDH-PQQ)的葡萄糖自我监测系统;使用ico-dextrin溶液治疗腹膜透析(PD)患者的血糖已得到充分证明。但是,仍存在因误读血糖而引起的不良降血糖事件。我们的目的是研究在使用艾考糊精转换的PD患者中,同时使用不同方法同时测量的血糖水平,以及是否使用艾考糊精进行每日交换。设计:我们招募了100名PD患者,其中40例使用艾考糊精; 128例血液透析患者作为参考。使用我们的实验室参考方法(LAB)和2个分别基于葡萄糖脱氢酶烟酰胺腺苷二核苷酸(GDH-NAD)和GDH-PQQ的葡萄糖自我监测系统,测量空腹血清葡萄糖。 80名PD患者进行了第二次随访研究。在每天的交流过程中,使用2个葡萄糖自我监测系统通过测量指尖葡萄糖,对16名PD患者进行了时程研究。结果血浆中(PQQ减去LAB)与(NAD减去LAB)的血糖水平差异显着增加。与其他患者组相比,使用艾考糊精的PD患者,并在后续研究中进一步证实了转用艾考糊精的患者。使用艾考糊精溶液的患者在一天的所有交流中均存在基于GDH-PQQ的葡萄糖自我监测系统测得的高血清葡萄糖结论。使用艾考糊精的患者中存在这种系统。为避免对高血糖症的误解和随后的胰岛素过度注射。PD患者不应使用基于GDH-PQQ的葡萄糖自我监测系统。

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