Re: Hara et al.: Decline of the red cell blood count in patients receiving androgen deprivation therapy for localized prostate cancer: impact of ADT on insulin-like growth factor 1 and erythropoesis. (Urology 2010;75:1441-1445).

摘要

The study of Hara et al. is very valuable because of the high prevalence of castration-related anemia (CRA) in patients with prostate cancer. From the study data, it is likely that the stimulation by testosterone on erythropoi-esis could be supported and/or amplified by insulin-like growth factor-1 (IGF-I) at a later stage. From this view, it is not surprising that the authors have found no correlation between pre- and post-androgen deprivation therapy (ADT) hematopoietic parameters and androgen levels. Even low levels of testosterone might be able to make erythron sensitive to a subsequent growth stimulation as mediated by IGF-I, which would otherwise be refractory. It is known that testosterone directly stimulates erithropoiesis; however, it is unclear whether testosterone directly increases the IGF-I receptor expression.