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Physiologic variations of serum testosterone within the normal range do not affect serum prostate-specific antigen.

机译:血清睾丸激素在正常范围内的生理变化不会影响血清前列腺特异性抗原。

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摘要

OBJECTIVES. To determine the relationship between endogenous total serum testosterone levels and serum prostate-specific antigen (PSA) concentrations. If a correlation exists between these two parameters, then use of testosterone-specific reference ranges may enhance the utility of PSA as a marker for prostate cancer. METHODS. Data were obtained from 150 men without previous history of prostate cancer. PSA was measured by the Abbott IMX microparticle enzyme immunoassay and total testosterone determined by the Coat-A-Count radioimmunoassay. RESULTS. No correlation was found between testosterone and PSA, even when corrected for age and weight. CONCLUSIONS. The data suggest that determination of the total serum testosterone level does not improve the sensitivity or specificity of PSA as a tumor marker.
机译:目标确定内源性血清总睾丸激素水平与血清​​前列腺特异性抗原(PSA)浓度之间的关系。如果这两个参数之间存在相关性,则使用睾丸激素特异性参考范围可能会增强PSA作为前列腺癌标志物的效用。方法。数据来自150名无前列腺癌史的男性。通过Abbott IMX微粒酶免疫测定法测量PSA,通过Coat-A-Count放射免疫测定法测定总睾丸激素。结果。即使校正了年龄和体重,也未发现睾丸激素和PSA之间存在相关性。结论。数据表明确定血清总睾丸激素水平不会提高PSA作为肿瘤标志物的敏感性或特异性。

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