Interpretive limitations associated with plasma volume shifts in the clinical assessment of hemostasis

摘要

We read with interest the recent publication by Austin et al. (1), where the authors analyzed blood from healthy males before and after the Tier Social Stress Test for markers of coagulation activation. They then reconstituted the samples for changes in plasma volume (PV) using participants' prestress plasma and saline and mathematically using the methods of Dill and Costill (2). They concluded that observed changes in coagulation were, in part, a consequence of stress and hemoconcentration and that the method of correction by Dill and Costill is not optimal for PV correcting coagulation times. They concluded by suggesting that saline reconstitution was a more "biologically relevant" method of correction.