A practical and. versatile entry into α-amino boronic esters via iridium-catafyzed chemose!ective and enantioselective hydrogenation of boron moiety containing vinyl chlorides

摘要

α-Amino boronic acids have attracted considerable attention recently due to their increased importance in biology, where they represent key building blocks of anti-cancer and diabetes drugs. Herein, we provide a concise review on the evolution of synthetic approaches to α-amino boronic acids and their derivatives. Furthermore, we highlight in detail the approach based on the chemoselective homogenous asymmetric hydrogenation of (1-chloro-1-alkenyl)boronic esters to chiral (α-chloroalkyljboronic esters and their transformation to a-amino boronic esters.