Comment on: 'Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice' (Magnani P, Conforti A, Zanolin E, Marzotto M and Bellavite P, Psychopharmacology, 2010)

摘要

In a recent article, "Dose-effect study of Gelsemium semper-virens in high dilutions on anxiety-related response in mice" {Psychopharmacology 2010, 210: 533-545), Magnani et al. claimed to provide solid evidence that Gelsemium sempervi-rens centesimal dilutions have anxiolytic-like effects in ICR-CD1 mice. This was based on the finding that, with a nonlinear relationship, the centesimal (C) dilution of G. sempervirens 5 C, 9 C and 30 C, but not 4 C and 7 C, modified mice behaviour in the Light Dark test. The result was not confirmed in the Open Field test.