Courses of aripiprazole-associated tardive dyskinesia: report of two cases.

摘要

Tardive dyskinesia (TD) is a syndrome of involuntary movements, consisting of abnormal, involuntary, irregular choreoathetoid movements of muscles over the head, limbs, and trunk. It usually develops in predisposed individuals during 6 months of antipsychotic drug treatment or longer. With the unique drug profile of partial dopamine D2 receptor agonist, partial 5-HT_1A agonist, and 5-HT_2A antagonist (Shapiro et al., 2003), aripiprazole is associated with unpredictable consequences in terms of TD. There have been case reports of emerging TD after use of aripiprazole (Evcimen et al., 2007; Maytal et al., 2006; Sajbel et al., 2005), while some reports demonstrate improvement of TD following aripiprazole therapy (Duggal, 2003; Grant and Baldessarini, 2005; Lykouras et al., 2007; Witschy and Winter, 2005). Here we present courses of aripiprazole-associated TD of two cases with different outcomes of dyskinesia.