Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats

摘要

The appetite-stimulating properties of cannabis are well documented and have been predominantly attributed to the hyperphagic activity of the psychoactive phytocannabinoid, a dagger(9)-tetrahydrocannabinol (a dagger(9)-THC). However, we have previously shown that a cannabis extract devoid of a dagger(9)-THC still stimulates appetite, indicating that other phytocannabinoids also elicit hyperphagia. One possible candidate is the non-psychoactive phytocannabinoid cannabigerol (CBG), which has affinity for several molecular targets with known involvement in the regulation of feeding behaviour.