Association study of polymorphisms in the autosomal mitochondrial complex I subunit gene, NADH dehydrogenase (ubiquinone) flavoprotein 2, and bipolar disorder.

摘要

The mitochondrial dysfunction hypothesis of bipolar disorder (BPD) was proposed based on a maternal inheritance pattern in family-based studies (McMahon et al., 1995). For the BPD linkage signal around human chromosome 18p11.2, Gershon et al. (1996) found a parent-of-origin effect only when maternal and paternal inheritances were considered. An autosomally encoded mitochondrial protein imported into the mitochondria to carry out important functions might explain this finding. NDUFV2, encoding the 24-kDa subunit of mitochondrial complex I, is one such gene found within the aforementioned BPD linkage region.