INCORPORATING N-VINYL-2-PYRROLIDONE INTO POLYACRYLONITR1LE BY WATER-PHASE PRECIPITATION COPOLYMER1ZATION TO IMPROVE ITS BIOCOMPATIBILITY

摘要

Polyacrylonitrilc (PAN) and acrylonitrile-based eopolymers have been successfully applied as membrane materials in the fields of dialysis, ultrafiltration, enzyme immobilization and pervaporation. However, because of the relatively poor hydrophilicity and/or biocompatibility for this type of membrane, some additional processes, such as chemical modification, biomacromolecule tethering (e.g. heparin), and cell seeding techniques must be taken to reduce the protein adsorption and prevent the blood clotting in hemodialysis.1 Since both good hemocompatibility and suitable flux are required for hemodialysis membrane, it is important to minimize the membrane-protein interactions which will irreversibly induce the membrane biofouling as well as activate the blood coagulation process. These interactions arc related to the chemical structure, the hydrophilicity/ hydrophobicity balance, the morphology (i.e. the domain structure of a multi-component system), and the topography (i.e. the surface roughness) of the membrane surface.' Af-Vinyl-2-pyrrolidone (NVP) is a potential monomer for the chemical modification of polymeric membranes mainly for its amphiphilic and biocompatible characteristics. It has been reported that poly(iV-vinyl-2-pyrrolidone) (PVP) is an attractive coating material for its superior biocompatibility and lubricity. The coating of PVP can evidently result in improved hemocompatibility with no need to invoke tissue engineering techniques including endothelial cell seeding.2 In addition, this versatile NVP monomer can be easily obtained and has the potential to be used on a large scale.