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Change in plasma visfatin level after severe traumatic brain injury

机译:严重颅脑损伤后血浆visfatin水平的变化

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Higher plasma visfatin concentration has been associated with ischemic stroke. Thus, we sought to investigate change in plasma visfatin level after traumatic brain injury and to evaluate its relation with disease outcome. Seventy-six healthy controls and 98 patients with acute severe traumatic brain injury were recruited. Twenty-seven patients (27.6%) died and 48 patients (49.0%) suffered from unfavorable outcome (Glasgow outcome scale score of 1-3) in 6 months. On admission, plasma visfatin level was increased in patients than in healthy controls and was highly correlated with Glasgow Coma Scale score. A multivariate analysis identified plasma visfatin level as an independent predictor for 6-month mortality and unfavorable outcome. According to receiver operating characteristic curve analysis, the predictive value of the plasma visfatin concentration was similar to Glasgow Coma Scale score's. In a combined logistic-regression model, visfatin did not improve the predictive value of Glasgow Coma Scale score. Thus, increased plasma visfatin level is associated with 6-month clinical outcomes after severe traumatic brain injury.
机译:血浆visfatin浓度升高与缺血性卒中有关。因此,我们试图研究颅脑外伤后血浆visfatin水平的变化,并评估其与疾病预后的关系。收集了76名健康对照和98例急性重度颅脑外伤患者。在6个月内,有27例患者(27.6%)死亡,48例患者(49.0%)出现不利的预后(格拉斯哥预后评分为1-3)。入院时,患者血浆visfatin水平高于健康对照组,并且与格拉斯哥昏迷量表评分高度相关。一项多变量分析确定血浆visfatin水平是6个月死亡率和不良结局的独立预测因子。根据接受者的工作特征曲线分析,血浆visfatin浓度的预测值与格拉斯哥昏迷量表评分相似。在联合逻辑回归模型中,visfatin不能改善格拉斯哥昏迷量表评分的预测价值。因此,严重的颅脑外伤后血浆visfatin水平升高与6个月的临床预后相关。

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