The role of NF-kappa B transcription factor in chronic viral hepatitis C and B

摘要

Essential data pertaining to the structure and function of selected transcription factors such as NFAT,AP-1 and NF-kappaB in particular,are presented in the relation to viral hepatitis C and B.In chronic hepatitis C the activation of NF-kappaB is markedly modulated by viral proteins such as core protein and nonstructural ones,particularly NS5A and NS3.In hepatitis B the major factor influencing NF-kappaB function appears to be HBx protein.Effects of viral proteins on NF-kappaB function in relation to the course of hepatitis are complex.They participate in the perpetuation of inflammatory state in the liver,inhibit apoptosis of hepatocytes,as well as the differentiation of antigen-presenting cells (dendritic ones).The latter effect has deleterious impact on the formation of specific immune response to viral peptides.It seems that both viruses,C and B acquired the ability to modify NF-kappa B function in advantage for the pathogens in question.