Determination of Relative Configuration in Organic Compounds by NMR Spectroscopy and Computational Methods

摘要

Stereochemical features have a profound impact on a variety of molecular properties,such as chemical reactivity and catalytic,biological,and pharmacological activities.In light of the above considerations,full stereochemical knowledge of a given system is of fundamental importance in many different fields,spanning from chemical physics to biochemistry.For this reason,the assignment of the configurational pattern in chiral organic compounds containing more than one stereocenter is undoubtedly a key step of the structure elucidation process.Due to the challenge typically posed by such configurational assignments,the search for new and more effective methods for the stereochemical analysis of complex molecular systems has stimulated great attention within the chemical community,having relevant implications to several distinct research areas,such as natural product chemistry,asymmetric synthesis,medicinal chemistry,chemical biology,and material sciences.