Exposure to polycyclic aromatic hydrocarbons and excretion of urinary 3-hydroxybenzo[a]pyrene:Assessment of an appropriate sampling time

摘要

Biomonitoring of workers was carried out in seven workplaces-two aluminium plants,an electrometallurgy plant,two carbon brake disk factories,a creosoting workshop,and an artificial target factory-to assess exposure to polycyclic aromatic hydrocarbons (PAHs).At least all the 48 h voided urine samples were collected,the first urine before the preshift at the beginning of the week and the last one after the preshift of the third day.The 3-hydroxybenzo[a]pyrene (3-OHBaP) and ]-hydroxypyrene (1-OHPy) in each urine sample were then analyzed separately by methods developed by INRS.Concentration profiles were determined.They indicate a considerable lag between the maximum excretion of the two metabolites.Including the previously published data obtained with workers exposed to PAHs,this varies from 3 to 24 h (mean lag = 15 h,n = 42).In order to determine the most appropriate sampling time for 3-OHBaP,the time of the 3-OHBaP maximum concentration is compared with the preshift.