A novel taxane 13-glucoside and other taxanes from the leaves of Taxus cuspidata.

摘要

Three new taxanes, 2 alpha,9 alpha,10 beta-triacetoxy-13 alpha-( beta-D-glucopyranosyloxy)taxa-4(20),11-dien-5 alpha-ol, 5 alpha,10 beta,13 alpha-triacetoxytax-11-ene-2 alpha,7 beta,9 alpha,20-tetraol, and 5 alpha,10 beta,13 beta-triacetoxy-2 alpha,7 beta-dihydroxy-2(3-->20) abeotaxa-4(20),11-dien-9-one, were isolated from the leaves of the Japanese yew, Taxus cuspidata. Compound 1 is the first example of a taxane with 13-glycosidic linkage.