The anorectic effects of alpha-lipoicacid are mediated by central AMPK and are not due to taste aversion in chicken (Gallus gallus)

摘要

AMP-activated protein kinase (AMPK) is an evolutionary conserved cellular energy sensor, which plays a pivotal role in mammalian energy homeostasis. The present study was aimed to explore the possible involvement of hy-pothalamic AMPK in feed intake regulation of broiler chickens. Hence, diets with 0,0.05% or 0.1% alpha-lipoicacid (alpha-LA), a known AMPK inhibitor in mammals, were provided to broiler chicks for 7 days. Alpha-LA exerted an anorectic effect, and the conditioned taste aversion test demonstrated that the effect was due to the alteration in satiety and not taste effects. However, the curtailed feed intake induced by alpha-LA disappeared on day 7. Hypothalamic AMPKalpha1 mRNA levels were significantly decreased by the dietary alpha-LA in concert with the reduced abundance in total AMPKalpha protein.