Clopidogrel pathway.

摘要

After oral- administration, clopidogrel is rapidly absorbed. Owing to its extensive metabolism, clopidogrel is not detected in human plasma. Clopidogrel is a prodrug that is absorbed in the intestine [3,4] and activated in the liver [5]. The conversion of clopidogrel to its active metabolite requires two sequential oxidative steps. As shown in Fig. 1, the first step leads to formation of 2-oxo-clopidogrel, followed by the conversion of 2-oxo-clopidogrel to the active metabolite. GYP1A2, GYP2B6, CYP2C9, CYP2G19, and CYP3A4/5 are implicated as cytochrome P450 enzymes involved in the metabolism of clopidogrel.