Chemical composition and antimicrobial activity of the essential oils of Geranium columbinum L. and G. lucidum L. (Geraniaceae)

摘要

The chemistry of Geranium columbinum and G. lucidumvolatiles has been studied here for the first time. The essentialoils were obtained by hydrodistillation, analyzed by GC and GC-MS, andscreened for their in vitro antibacterial and antifungal activity in amicrodilution assay. In total, 172 constituents were identified,accounting for 88.1%-96.7% of the detected GC peak areas. Theessential oils consisted mainly of fatty acids and fatty acid-derivedcompounds (65.0%-86.3%). The major compounds of the essential oilswere hexadecanoic acid, hexahydrofarnesyl acetone, and tetracosane.The antimicrobial assay showed a strong activity of the oil fromaerial parts of G. columbinum against the pathogenic yeast C. albicans(MIC = 0.437, MBC = 1.75 mg/mL).