The Bioinformatics analysis of Growth hormone or Somatotropin structure in animals

摘要

For many years, scientists have known. that the crude extract of pituitary glands has substance which effects ongrowth animals treated with. They named this substance growth hormone. Many years later growth hormone(GH) or Somatotropin (ST) extracted from anterior pituitary glands. Now, it is revealed that ST simulate growthand milk production and reduces the amount of carcass fat in many animals. Studies showed that bovine ST hasno effect on human body, it revealed that protein sequences of ST differ in human and animals. In this studybioinformatics analysis of ST protein sequences, using existent data in UniProt database and Gene bank carriedout. Results showed that while ST protein sequences is much conserved in animals but, there is many differencesamong mammals' ST sequences; especially in human, compare to other animals. Based on results of this study,selected animals (Ovis. aries, Bos. taurus, Capra. hircus, Homo. sapiens, Mus musculus, Rattus norvegicus,Equus caballus, Sus scrofa) ST arranged into 4 groups, and human ST had most difference with other animals.