首页> 外文期刊>World Journal of Urology >Urocortin and corticotropin-releasing factor receptor 2 in human renal cell carcinoma: disruption of an endogenous inhibitor of angiogenesis and proliferation
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Urocortin and corticotropin-releasing factor receptor 2 in human renal cell carcinoma: disruption of an endogenous inhibitor of angiogenesis and proliferation

机译:人肾细胞癌中的Urocortin和促肾上腺皮质激素释放因子受体2:内源性血管生成和增殖抑制剂的破坏

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Purpose Urocortin (Ucn) exerts its actions through activation of two corticotropin-releasing factor receptors (CRFRs), CRFR1 and CRFR2. Involvement of Ucn/CRFR2 system in pathophysiological conditions such as the regulation of angiogenesis and inhibition of proliferation has been already reported. Suppression of neovascularization through reduction of vascular endothelial growth factor and inhibition of tumor cell cycling is modulated mainly through activation of CRFR2. To find out a possible involvement of Ucn/CRFR2 in kidney tumor, we examined the expression of Ucn and CRFR2 in normal and tumoral kidney specimens.
机译:目的Urocortin(Ucn)通过激活两个促肾上腺皮质激素释放因子受体(CRFRs)CRFR1和CRFR2发挥作用。已经报道了Ucn / CRFR2系统参与病理生理状况,例如调节血管生成和抑制增殖。通过减少血管内皮生长因子和抑制肿瘤细胞周期来抑制新血管形成主要通过激活CRFR2来调节。为了发现Ucn / CRFR2可能参与肾脏肿瘤,我们检查了正常和肿瘤肾脏标本中Ucn和CRFR2的表达。

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