Akt signalling parameters are different in oncocytomas compared to renal cell carcinoma

摘要

Renal oncocytomas are assigned as benign tumours, and their detailed molecular mechanism is poorly characterised. Activation of the PKB/Akt pathway is assumed to contribute to the pathogenesis and progression of malignant disease. For oncocytomas, hardly any data are available for Akt signalling parameters. Aim of the present work was to determine the alterations of Akt parameters PTEN, phosphorylated Akt (p-Akt) and p27Kip1 in oncocytoma to better understand the dedifferentiation of renal tumours.