Non-Isothermal Kinetics of Thermal Decomposition of a Novel Antitumor Agent 4-{5-[3,4-Dimethyl-5 -(3,4,5-Trimethoxyphenyl)Thiophen-2-yl] -2-Methoxyphenyl} Morpholine

摘要

The thermal decomposition of a new antitumor agent. 4-{5-[3,4-dimethyl-5-(3,4, thoxyphenynthiophen-2-yl]-methoxyphenyl} morpholine was studied by Differential Scanning Calorimetry (DSC) and Thermogravimetry (TG)/ Derivative Thermogravimetry (DTG) methods at a flow rate of nitrogen gas of 120 mL/min. The kinetic parameters were obtained from the analysis of the corresponding curves by Kissinger's method, Ozawa's method and the integral method. The results indicate that the apparent activation energy and pre-exponential constants of the decomposition reaction are 106,67 kJ/mol and 10~(6.19) s~(-1), respectively.