Kinetic Study of Asymmetric Hydrogenation of α, β-Unsaturated Carboxylic Acid Over Cinchona-Modified Pd/Al2O3 Catalyst

摘要

The enantioselective hydrogenation of 2-methyl-2-pentenoic acid (MPeA) over cinchonidine-modified 5 wt % Pd/γ-Al2O3 catalyst has been studied. The reaction exhibited a strong solvent-dependent behavior in terms of activity. The presence of cinchonidine does not affect the reaction order with respect to either acid or H2 pressure, but has a significant inhibiting effect on the reaction rate.