HPLC DETERMINATION OF GUAJAZULENE IN THE PHARMACEUTICAL PRODUCT ROMAZULAN

摘要

A liquid-chromatographic method for the determination of guajazulene in the pharmaceutical product Romazulan was presented. For the isolation of guajazulene from the very complex matrix of the hydroalcoholic extract of Matricaria chamomilla a selective liquid-solid extraction on a C_(18) reversed phase cartridge was performed. Acceptable values for average recovery, standard deviation and variation coefficient were obtained.